A chrysin analog exhibited strong inhibitory activities against both PGE2 and NO production

Che, Haiyan; Lim, Hyun; Kim, Hyun Pyo; Park, Haeil

doi:10.1016/j.ejmech.2011.04.044

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A chrysin analog exhibited strong inhibitory activities against both PGE2 and NO production

Che, Haiyan;
Lim, Hyun;
Kim, Hyun Pyo;
Park, Haeil

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WEB OF SCIENCE

35

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37

초록

A number of 8-substituted chrysin analogs have been prepared and evaluated for their inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin E-2 and iNOS-mediated NO production. Analogs were prepared via Suzuki-Miyaura C-C cross coupling reaction of 8-iodo-5,7-dimethoxyflavone and alkyl/areneboronic acids as a key reaction. Among the analogs tested, 5,7-dihydroxy-8-(pyridine-4-yl) flavone (3d) showed strong biological activities against COX-2 catalyzed PGE(2) and iNOS-mediated NO production from LPS-induced RAW 264.7 cells compared to those of chrysin. (C) 2011 Elsevier Masson SAS. All rights reserved.

키워드

8-Substituted chrysin analogs; Wogonin; Inflammation; PGE(2); NO; Suzuki-Miyaura reaction; NITRIC-OXIDE SYNTHASE; FLAVONOIDS; MACROPHAGES; DERIVATIVES; CELLS

제목: A chrysin analog exhibited strong inhibitory activities against both PGE2 and NO production

저자: Che, Haiyan; Lim, Hyun; Kim, Hyun Pyo; Park, Haeil

DOI: 10.1016/j.ejmech.2011.04.044

발행일: 2011-09

유형: Article

저널명: European Journal of Medicinal Chemistry

권: 46

호: 9

페이지: 4657 ~ 4660