고농도 불소치약과 나노하이드록시 아파타이트 함유 치약의 법랑질 재광화 효과 비교 분석

초록

Objectives: This study compared the remineralization effects of high-concentration fluoride toothpaste (1,450 ppm) and nanoh ydroxyapatite (nano-HAp) toothpaste on demineralized enamel using a pH-cycling model. Methods: Ninety enamel specimens were prepared from 30 healthy maxillary first premolars and divided into six groups: a negative control (untreated), a positive control group (demineralization only), high-concentration fluoride toothpaste applied for 3 days (Group 3) and 6 days (Group 4), and nano-HAp toothpaste applied for 3 days (Group 5) and 6 days (Group 6). Specimens were demineralized for 4 days, followed by 12 days of pH cycling. Remineralization was evaluated using scanning electron microscopy (SEM) to assess microstructural changes and energy-dispersive X-ray spectroscopy (EDS) to quantitatively analyze calcium (Ca) and phosphorus (P) content. Results: Both toothpastes demonstrated significant remineralization effects. High-concentration fluoride toothpaste produced a modest increase in calcium (Ca) and phosphorus (P) content after 3 days of treatment, with no significant additional remineralization observed over time. In contrast, 6 days of nano-HAp toothpaste application resulted in higher Ca (62.98 ± 6.38 at%) and P (46.51 ± 1.75 at%) contents than those observed in the high-concentration fluoride toothpaste group. Moreover, the nano-HAp 6-day group exhibited the smoothest enamel surface morphology among all experimental groups based on SEM observations. Conclusions: Nano-HAp toothpaste demonstrated greater remineralization efficacy than fluoride toothpaste. These findings suggest that nano-HAp toothpaste may have potential as a basis for developing future remineralizing toothpaste formulations.

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