Canine Renal Failure Caused by Ochratoxin A and Citrinin in the Commercial Dog Food

초록

Five dogs with renal failure were refered to the Veterinary Medical Teaching Hospital at Kangwon Nationalfor over 1 month. The dogs showed anorexia, emaciation, vomiting, and polydipsia/polyuria. And in one severelyaffected dog, bloody diarrhea and hypothermia were seen. The remarkable clinicopathological signs were high valueof BUN and creatinine. In some dogs, GGT, phosphorus and lipase were increased. However, no significant changesof complete blood count were found. In urinalysis, hematuria, low specific gravity urine, proteinuria, and calciumoxalate-like crystals were observed. Two severely affected dogs were died. The remained dogs were recovered graduallyafter change of dog food and supportive therapy. Pathological findings were seen typically in kidneys. Renal atrophy,tion, necrosis, dystrophic calcification and regeneration inthe tubular epithelium were seen. Yellowish brown fluorolucent laminated materials or particles were quite often foundin the lumina of the necrotizing renal tubules of cortex and medulla. Proliferation of fibrous tissue in the interstitiumwas also seen. By the mycotoxin analysis of the Pedigree dry dog fod, ochratoxin A (OTA) and citrinin were detectedas much as the concentration of 372.8 ppb and 8.3 ppb, respectively. The final diagnosis of renal failure caused byOTA and citrinin toxicosis was made on the basis of history takings, clinical signs, clinicopathological and pathologicalfindings, and analysis of mycotoxins.

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