Calpain inhibitory flavonoids isolated from Orostachys japonicus

Ma, Choong Je; Jung, Won Joo; Lee, Ki Yong; Kim, Young Choong; Sung, Sang Hyun

doi:10.1080/14756360802328075

상세 보기

Calpain inhibitory flavonoids isolated from Orostachys japonicus

Ma, Choong Je;
Jung, Won Joo;
Lee, Ki Yong;
Kim, Young Choong;
Sung, Sang Hyun

Citations

WEB OF SCIENCE

31

Citations

SCOPUS

34

초록

The n-butanol (n-BuOH) fraction of Orostachys japonicus A. Berger (Crassulaceae) significantly inhibited calpain activity. Through the activity-guided isolation from the n-BuOH fraction, herbacetin 8-O-alpha-D-ribopyranoside (1), kaempferol (2), quercetin (3), afzelin (4), astragalin (5), isoquercetin (6) and quercitrin (7) were obtained. Their structures were determined by spectroscopic techniques. Among them, compound 3 and 5 had significant calpain inhibitory activities.

키워드

Orostachys japonicus; flavonoid; calpain; neuroprotection; inhibition; QUERCETIN

제목: Calpain inhibitory flavonoids isolated from Orostachys japonicus

저자: Ma, Choong Je; Jung, Won Joo; Lee, Ki Yong; Kim, Young Choong; Sung, Sang Hyun

DOI: 10.1080/14756360802328075

발행일: 2009

유형: Article

저널명: Journal of Enzyme Inhibition and Medicinal Chemistry

권: 24

호: 3

페이지: 676 ~ 679