Biomolecule-Based Nanorobot for Targeted Delivery of Therapeutics

초록

Rapid progress in biomedical engineering has allowed the design of nanoscale biomolecular nanodevices that act as smart nanobots. The realization of nanometer-sized robots assembled from biomolecules is one of the goals of targeted drug delivery and therapy. Numerous self-propelling nanobots capable of intrinsic navigation in biological fluids with enhanced pharmacokinetics and deep tissue-penetrating efficacy have shown potentiality in disease diagnosis and targeted therapy, including diabetes, cancer, infectious disease, hypertension, and depression, among others. The structural and compositional aspects of fabricated nanobots determine their successful application. Among the extensively used materials, DNA and functional proteins like antibodies, contractile proteins, and enzymes have been significantly explored for designing and manufacturing nanobots. This chapter describes the development of biomolecule-based nanobots in the realm of on-demand drug delivery under the effect of intrinsic and external stimuli. Furthermore, the challenges and prospects of the technology have also been vastly explored. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.

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