Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1β and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells

Hwang, MH; Lim, JH; Yun, HI; Rhee, MH; Cho, JY; Hsu, W; Park, SC

doi:10.1007/s10529-005-2515-1

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Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1β and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells

Hwang, MH;
Lim, JH;
Yun, HI;
Rhee, MH;
Cho, JY;
외 2명

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28

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30

초록

The anti-inflammatory activity of the surfactin C derived from Bacillus subtilis isolate was investigated in lipopolysaccharide (LPS, 1 mu g ml(-1))-treated mouse RAW 264.7 cells. LPS increased mRNA transcription of cyclooxygenase (COX)-2, interleukin (IL)-1 beta and inducible nitric oxide synthase (iNOS). However, surfactin C at 50 mu g ml(-1) inhibited the LPS-induced increase in the transcription of IL-1 beta and iNOS and nitric oxide (NO) production in a dose-dependent manner.

키워드

cytokine; cyclooxygenase; interleukin-1 beta; nitric oxide; surfactin; SUPPRESSION; CULTURE

제목: Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1β and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells

저자: Hwang, MH; Lim, JH; Yun, HI; Rhee, MH; Cho, JY; Hsu, W; Park, SC

DOI: 10.1007/s10529-005-2515-1

발행일: 2005-10

유형: Article

저널명: Biotechnology Letters

권: 27

호: 20

페이지: 1605 ~ 1608