Cytotoxic terpenoids from Juglans sinensis leaves and twigs

Yang, Heejung; Cho, Hyun-Jong; Sim, So Hee; Chung, Young Keun; Kim, Dae-Duk; Sung, Sang Hyun; Kim, Jinwoong; Kim, Young Choong

doi:10.1016/j.bmcl.2012.01.010

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Cytotoxic terpenoids from Juglans sinensis leaves and twigs

Yang, Heejung;
Cho, Hyun-Jong;
Sim, So Hee;
Chung, Young Keun;
Kim, Dae-Duk;
외 3명

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24

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27

초록

Bioassay-guided fractionation of an 80% MeOH extract of Juglan sinensis leaves and twigs has resulted in the isolation of three new triterpenes (1-3) and two new sesquiterpenes (4-5) along with two known sesquiterpenes (6-7). The new compounds were determined to be 3 beta, 11 alpha, 19 alpha, 24, 30-pentahydroxy-20 beta, 28-epoxy-28 beta-methoxy-ursane (1), 1 alpha, 3 beta-dihydroxy-olean-18-ene (2), 2 alpha, 3 alpha, 23-trihydroxy-urs-12-en-28-oic acid 28-O-beta-D-glucopyranoside (3), (4S, 5S, 7R, 8R, 14R)-8, 11-dihydroxy-2, 4-cyclo-eudesmane (4), 15-hydroxy-alpha-eudesmol-11-O-beta-D-glucopyranoside (5), by spectroscopic analysis. The cytotoxicity of compounds (1-7) against four cancer cell lines such as B16F10, Hep-2, MCF-7 and U87-MG was evaluated. Compounds 1, 2, 6 and 7 showed potent cytotoxicity against all of four cancer cell lines, respectively. (C) 2012 Elsevier Ltd. All rights reserved.

키워드

Juglans sinensis; Triterpenes; Sesquiterpenes; Oleanane; Ursane; Eudesmane; C-13 NMR-SPECTRA; CONSTITUENTS; DERIVATIVES; EXTRACTS; ACID; H-1

제목: Cytotoxic terpenoids from Juglans sinensis leaves and twigs

저자: Yang, Heejung; Cho, Hyun-Jong; Sim, So Hee; Chung, Young Keun; Kim, Dae-Duk; Sung, Sang Hyun; Kim, Jinwoong; Kim, Young Choong

DOI: 10.1016/j.bmcl.2012.01.010

발행일: 2012-03-01

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 22

호: 5

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