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Anti-inflammatory Activity of Pyrrolizidine Alkaloids from the Leaves of Madhuca pasquieri (Dubard)
- Hoang, Le Son;
- Manh Hung Tran;
- Lee, Joo Sang;
- Dao Cuong To;
- Van Thu Nguyen;
- ... Lee, Jeong Hyung;
- 외 3명
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20초록
A novel pyrrolizidine alkaloids, madhumidine A (1), and two known alkaloids, lindelofidine benzoic acid ester (2) and minalobine B (3) were isolated from the leaves of Madhuca pasquieri (Dubard) H. J. LAM. The chemical structures of these alkaloids were established mainly by NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cell. In addition, the cytotoxic activity of all isolated compounds was tested against a panel of cancer cell lines.
키워드
Madhuca pasquieri; Sapotaceae; lindelofidine-1-hydroxymethyl pyrrolizidine; TRITERPENOID SAPONINS; NO PRODUCTION
- 제목
- Anti-inflammatory Activity of Pyrrolizidine Alkaloids from the Leaves of Madhuca pasquieri (Dubard)
- 저자
- Hoang, Le Son; Manh Hung Tran; Lee, Joo Sang; Dao Cuong To; Van Thu Nguyen; Kim, Jeong Ah; Lee, Jeong Hyung; Woo, Mi Hee; Mie, Byung Sun
- 발행일
- 2015-06
- 유형
- Article
- 권
- 63
- 호
- 6
- 페이지
- 481 ~ 484
- 언어
- ENG
- 출판사
- PHARMACEUTICAL SOC JAPAN
- 발행국가
- 일본
- 분량
- 4 페이지
- ISSN
- E 1347-5223
P 0009-2363