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Novel small molecule activators of β-catenin-mediated signaling pathway: structure-activity relationships of indirubins
- Park, Eun-Jung;
- Choi, Soo Jeong;
- Kim, Yong-Chul;
- Lee, Sang Hyung;
- Park, Seoung Woo;
- 외 1명
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12Citations
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15초록
Based on the beta-catenin-drived Wnt activator of bromoindirubin-3'-oxime (BIO), indirubin analogs were evaluated for beta-catenin-mediated gene expression. A novel indirubin analog, indirubin-5-nitro-3'-oxime (INO), was considered a potential activator, and structure-activity studies were conducted with indirubins. These data suggest that INO might be a novel Wnt activator and has a potential of signaling regulator in beta-catenin-mediated signaling pathways. (c) 2009 Elsevier Ltd. All rights reserved.
키워드
Wnt signaling; Novel activator of Wnt signaling; Indirubin; 5-Nitro-3 '-monoxime; beta-Catenin; WNT; KINASE; DERIVATIVES; INHIBITORS; ADHESION
- 제목
- Novel small molecule activators of β-catenin-mediated signaling pathway: structure-activity relationships of indirubins
- 저자
- Park, Eun-Jung; Choi, Soo Jeong; Kim, Yong-Chul; Lee, Sang Hyung; Park, Seoung Woo; Lee, Sang Kook
- 발행일
- 2009-04-15
- 유형
- Article
- 권
- 19
- 호
- 8
- 페이지
- 2282 ~ 2284
- 언어
- ENG
- 출판사
- PERGAMON-ELSEVIER SCIENCE LTD
- 발행국가
- 영국
- 분량
- 3 페이지
- ISSN
- E 1464-3405
P 0960-894X