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Diterpenoids isolated from the root of Salvia miltiorrhiza and their anti-inflammatory activity
- Thi Men Ngo;
- Phuong Thao Tran;
- Hoang, Le Son;
- Lee, Jeong-Hyung;
- Min, Byung Sun;
- 외 1명
Citations
WEB OF SCIENCE
25Citations
SCOPUS
24초록
Four new diterpene-type compounds normiltirone (3) and isosalviamides F-H (14-16) together with twelve known compounds (1, 2, 4-13) were isolated from the roots of Salvia miltiorrhiza. Their structures were mainly elucidated from detailed spectroscopic data. All isolated compounds were evaluated for their ability to inhibit lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages. Compound 11 showed a strong inhibitory effect, with an IC50 value of 3.4 +/- 1.2 mu M.
키워드
Salvia miltiorrhiza; diterpene alkaloid; anti-inflammatory activity; nitric oxide production; TANSHINONE-IIA; CONSTITUENTS; EXPRESSION; BUNGE; INHIBITION; CHEMISTRY; CELLS
- 제목
- Diterpenoids isolated from the root of Salvia miltiorrhiza and their anti-inflammatory activity
- 저자
- Thi Men Ngo; Phuong Thao Tran; Hoang, Le Son; Lee, Jeong-Hyung; Min, Byung Sun; Kim, Jeong Ah
- 발행일
- 2021-03-04
- 유형
- Article
- 권
- 35
- 호
- 5
- 페이지
- 726 ~ 732
- 언어
- ENG
- 출판사
- TAYLOR & FRANCIS LTD
- 발행국가
- 영국
- 분량
- 7 페이지
- ISSN
- E 1478-6427
P 1478-6419