상세 보기
Interleukin-2 promotes angiogenesis by activation of Akt and increase of ROS
- Bae, Jinhee;
- Park, Deokbum;
- Lee, Yun-Sil;
- Jeoung, Dooil
Citations
WEB OF SCIENCE
20Citations
SCOPUS
22초록
Interleukin-2 plays a significant role in T cell proliferation. Here, we report the role of IL-2 in angiogenesis. IL-2 increased the ROS level and phosphorylation of Akt in human umbilical vein endothelial cells (HUVECs). IL-2 increased angiogenesis in an animal model and tube formation in HUVECs. The effect of IL-2 on angiogenesis and tube formation was mediated by ROS and Akt. This is the first report that IL-2 promotes angiogenesis.
키워드
angiogenesis; interleukin-2; reactive oxygen species; serine/threonine kinase Akt; ENDOTHELIAL GROWTH-FACTOR; HUMAN T-CELLS; NK CELLS; IL-2 PRODUCTION; RECEPTOR; EXPRESSION; PROLIFERATION
- 제목
- Interleukin-2 promotes angiogenesis by activation of Akt and increase of ROS
- 저자
- Bae, Jinhee; Park, Deokbum; Lee, Yun-Sil; Jeoung, Dooil
- 발행일
- 2008-02
- 유형
- Article
- 권
- 18
- 호
- 2
- 페이지
- 377 ~ 382