Pharmaceutical Constituents Contents and Deviations in Korean and Chinese Cultivars of Salvia miltiorrhiza Root (Danshen) Followed by Crop Years

초록

Background: This study was conducted to determine color parameters, and identify pharmaceutical constituents and phytochemical characteristics of Korean cultivars (Hongdan, Dasan, and Kosan) of Salvia miltiorrhiza root (Danshen) by crop years compared with those of the Chinese cultivar [“Zhongdanyaozhi No. 1 (ZD1)”]. Methods and Results: Redness (a*), yellowness (b*), extract yield, salvianolic acid B (Sal B), and tanshinone IIA (TanIIA) were generally higer in Korean cultivars than in ZD1, implying effective quality control with Korean cultivars in Danshen. Sal B and TanIIA content were found to be the highest in Korean cultivar ‘Hongdan’ (3-fold higher than ‘ZD1’) in the 2020 crop year. Sal B was chosen as a major markers to assess Korean Danshen quality. However, Sal B detection was apparently incomplete and insufficient for quality control, because Sal B degradation was crop years dependent, Sal B was degraded to some small molecular phenolic acids, such as caffeic acid, protocatechuic aldehyde, lithospermic acid, and danshensu, which were elucidated by liquid chromatography. Analysis of Pearson’s correlation heatmap revealed negative correlation between Sal B and small phenolic acids. The Sal B content of Danshen was correlated to the redness of color parameter, the total terpenoid content, TanIIA content, suggesting that it would be reasonable to simultaneously detect these characteristics for Danshen quality control. Conclusions: This study provides constructive and meaningful references for the qualitative and quantitative analyses of S. miltiorrhiza root, which can help establish better quality standards. © 2024, Korean Society of Medicinal Crop Science. All rights reserved.

키워드