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초록
our continuing effort to investigate compounds having anti-inflammatory activity from natural products, Ail-anthus altissima was examined. Among six compounds isolated from Ailanthus altissima, Luteolin-7-O-glucoside (L7G) alongwith ethanol extract of Ailnathus altissima (EAa) were chosen to determine their inhibitory activity on secretory recombinantphospholipase A2s enzyme activity in vitro 2-V (IC50 of about 100g/ml) and cPLA2, (IC50 of about 59g/ml), while L7G showed strong inhibitory effect on sPLA2-A, V and cPLA2 with an IC50value of approximately 40M, respectively.Key wordsAilanthus altissima, Luteolin-7-O-glucoside, Phospholipase A2, inflamation... ... .... phospholipase A2(PLA2). ..... ...... arachidonic acid(AA) . lysophos-pholipid. .... . PLA2. .. ... AA. cyclooxy-genase(COX). lipoxygenase(LOX). .. ... ....... prostaglandins(PGs), thromboxanes(TXs) .leukotrienes(LTs). .. .... . .. ... lysophos-pholipid. .. .... .... ..... ... ...... .... platelet activating factor(PAF, ........ ). ..... PLA2. ... ...... .
키워드
- 제목
- 가죽나무 에타놀 추출물 및 luteolin-7-O-glucoside의phospholipase A2 저해활성
- 제목 (타언어)
- Inhibitory Activity of Ethanol Extracts of Ailanthus altissima andLuteolin-7-glucoside on Phospholipase A2 activity
- 저자
- 장현욱; 김미화; 황남경; 홍태균; 김윤경; 정환기; 양주혜; 전철구; 배기환; Pham Ngoc Thanh; 손건호; 김현표; 강삼식
- 발행일
- 2007-09
- 유형
- Y
- 저널명
- 생약학회지
- 권
- 38
- 호
- 3
- 페이지
- 277 ~ 280