Characterization of Antioxidant Activity and Anticancer Effect of an Endangered Plant, Lilium dauricum Ker-Gawl

초록

Background: Lilium dauricum Ker-Gawl is an endangered plant, and it is highly valued as a medicinal plant owing to its excellent functionality. Methods and Results: L. dauricum leaf extract was shown to have high antioxidant activity and an inhibition concentration of 50% (IC50)value of 71.8 ± 0.13 ㎍/㎖ was shown for 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity. Its total phenol and flavonoid contents were 74.76 ± 0.24 ㎎·gallic acid equivalent (GAE)/g and 31.44 ± 0.27 ㎎·quercetin equivalent (QE)/g, respectively. Nitric oxide (NO) production was measured after oxidative stress was induced in lipopolysaccharide-stimulated RAW 264.7 cells, and 200 ㎍/㎖ of leaf extract effectively inhibited NO production at a rate of 17.84 ± 0.18%. Gastric cancer cells (AGS) and lung cancer cells (A549) were treated with 200 ㎍/㎖ of bulb extract, the inhibition rate for gastric cancer cell growth was 48.12 ± 2.60% whereas the inhibition rate for lung cancer cell growth was 55.83 ± 4.08%. Conclusions: These results provide basic research data that can be used to identify the active constituents present in L. dauricum leaf and bulb extracts for the development of anticancer drugs, antioxidants, and functional products. © 2023 The Author.

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