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Facile Synthetic Method of Alkanethiol Spacer for Biointerface
- Cho, Hong-Jun;
- Park, Sung Jun;
- Kim, Jung Won;
- Lee, Sang-Myung;
- Lee, Yoon-Sik
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0초록
An alkanethiol spacer which is suitable for biointerface was synthesized on 2-chlorotritylchloride (CTC) resin using solid-phase synthesis method. The triethylene glycol (TEG) unit containing building block was immobilized on CTC resin followed by a coupling alkanethiol building block. After dithiothreitol (DTT) treatment and cleavage of the resulting alkanethiol spacer from the resin, the spacer was obtained in a pure form without any purification steps. The TEG-alkanethiol spacer was applied for the DNA hybridization assay on a gold surface, and proved to work well when compared to the commercial spacer.
키워드
alkanethiol; solid-phase synthesis; self-assembled monolayer; biointerface; nonspecific adsorption; SELF-ASSEMBLED MONOLAYERS; OPENING METATHESIS POLYMERIZATION; SURFACE-PLASMON RESONANCE; SOLID-PHASE SYNTHESIS; PROTEIN ADSORPTION; CELL-ADHESION; GOLD; HYBRIDIZATION; ATTACHMENT; BINDING
- 제목
- Facile Synthetic Method of Alkanethiol Spacer for Biointerface
- 저자
- Cho, Hong-Jun; Park, Sung Jun; Kim, Jung Won; Lee, Sang-Myung; Lee, Yoon-Sik
- 발행일
- 2013-01
- 유형
- Article
- 저널명
- Synlett
- 권
- 24
- 호
- 1
- 페이지
- 20 ~ 23