Ameliorating Effect of Astragalus sinicus Ethanol Extract on Dermal Aging

초록

Background: Skin aging is caused by two factors: Intrinsic factors such as genetics and extrinsic factors such as ultraviolet exposure. This study aimed to explore the ameliorating activity of etha-nol extract of Astragalus sinicus (ASE) on human skin fibroblast (HDFs) subjected to intrinsic and extrinsic aging via continuous culturing and UVB radiation, respectively. Methods and Results: Matrix metalloproteinase (MMP-1) mRNA expression and elastase activity were determined using qRT-PCR and ELISA, respectively. The activities of senescence-associ-ated β-galactosidase (SA-β-gal) with or without UVB exposure were investigated using enzyme histochemical staining assay. ASE treatment decreased MMP-1 expression and elastase activity. Furthermore, ASE treatment suppressed SA-β-gal activity in both UVB-exposed and UVB-free environments. Conclusions: These finding suggest that ASE has dermal anti-aging effects and can be employed as a functional cosmetic material. © 2022, Korean Society of Medicinal Crop Science. All rights reserved.

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