Current Trends in Engineered Gold Nanoparticles for Cancer Therapy

초록

In recent years, engineered smart nanomaterials are considered ideal candidates for the efficient treatment of cancers. Among all the engineered nanomaterials, gold nanomaterials (AuNPs) have been widely explored to thermal destruction of cancer due to their intrinsic properties such as optical, electronic, photothermal heating ability, physicochemical, and surface plasmon resonance (SPR), which can be altered by changing the size, shape, and aspect ratio of AuNPs. In this book chapter, we mainly focus on four different types of cancer therapies such as AuNP-mediated photothermal therapy, photodynamic therapy, radiotherapy, and glucose-starvation therapy. We begin with an introduction to the properties of the AuNPs and the heat-generating mechanism, which have been well established. Additionally, we also discuss the recent research findings with representative near-infrared-active AuNPs, including spherical nanoparticles, nanoshells, nanorods, nanostars, and nanocages. This includes in vitro and in vivo studies and the recent progression of AuNPs in cancer therapies. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.

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