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Neuroprotective lignans from Biota orientalis leaves
- Yoon, Jeong-seon;
- Koo, Kyung-ah;
- Ma, Choong-je;
- Sung, SangHyun;
- Kim, Young-choong
Citations
SCOPUS
15초록
We previously reported that 90% MeOH fraction of Biota orientalis leaves (L.) ENDL. had significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells. In the present study, (-)-savinin (1), (-)-hinokinin (2), dehydroheliobuphthalmin (3) were isolated by bioactivity-guided fractionation from the 90% MeOH fraction. All three lignans had significant neuroprotective activities against glutamate-induced neurotoxicity at the concentrations ranging from 0.1 to 10.0 μM.
키워드
(-)-hinokinin; (-)-savinin; Biota orientalis; Dehydroheliobuphthalmin; Glutamate; Primary cultures of rat cortical cells
- 제목
- Neuroprotective lignans from Biota orientalis leaves
- 저자
- Yoon, Jeong-seon; Koo, Kyung-ah; Ma, Choong-je; Sung, SangHyun; Kim, Young-choong
- 발행일
- 2008
- 유형
- Article
- 권
- 14
- 호
- 3
- 페이지
- 167 ~ 170