Synthesis and biological activities of 8-arylflavones

초록

A number of 8-arylflavones have been synthesized as congeners of wogonin and evaluated for their inhibitory activities of PGE(2) production. 8-Arylflavones were obtained from commercially available chrysin via two different synthetic pathways. Most 8-arylflavones exhibited much reduced inhibitory activities against COX-2 catalyzed PGE(2) production compared to that of wogonin. Functional group replacement at the 8-position of wogonin from methoxy to aryl group caused loss of inhibitory activity. Our present results imply that the functional group at the 8-position of flavones seems to play very important roles for bioactivity.

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