Therapeutic Implication of miRNAs as an Active Regulatory Player in the Management of Pain: A Review

Hassan, Mubashir; Shahzadi, Saba; Yasir, Muhammad; Chun, Wanjoo; Kloczkowski, Andrzej

doi:10.3390/genes15081003

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Therapeutic Implication of miRNAs as an Active Regulatory Player in the Management of Pain: A Review

Hassan, Mubashir;
Shahzadi, Saba;
Yasir, Muhammad;
Chun, Wanjoo;
Kloczkowski, Andrzej

Citations

WEB OF SCIENCE

6

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SCOPUS

8

초록

Chronic pain is frequently associated with neuropathy, inflammation, or the malfunctioning of nerves. Chronic pain is associated with a significant burden of morbidity due to opioid use, associated with addiction and tolerance, and disability. MicroRNAs (miRs) are emerging therapeutic targets to treat chronic pain through the regulation of genes associated with inflammation, neuronal excitability, survival, or de-differentiation. In this review, we discuss the possible involvement of miRs in pain-related molecular pathways. miRs are known to regulate high-conviction pain genes, supporting their potential as therapeutic targets.

키워드

miRNAs; pain; receptor; pain management; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CENTRAL-NERVOUS-SYSTEM; GROWTH-FACTOR-BETA; NEUROPATHIC PAIN; DOWN-REGULATION; NONCODING RNAS; VISCERAL PAIN; UP-REGULATION; TRANSPORTER EXPRESSION; INFLAMMATORY PAIN

제목: Therapeutic Implication of miRNAs as an Active Regulatory Player in the Management of Pain: A Review

저자: Hassan, Mubashir; Shahzadi, Saba; Yasir, Muhammad; Chun, Wanjoo; Kloczkowski, Andrzej

DOI: 10.3390/genes15081003

발행일: 2024-08

유형: Review

저널명: Genes

권: 15

호: 8