New polyhydroxytriterpenoid derivatives from fruits of Terminalia chebula Retz. and their α-glucosidase and α-amylase inhibitory activity

초록

Three new polyhydroxytriterpenoid derivatives, 23-O-neochebuloylarjungenin 28-O-beta-D-glycopyranosyl ester (1), 23-O-4'-epi-neochebuloylarjungenin (2), and 23-O-galloylpinfaenoic acid 28-O-beta-D-glucopyranosyl ester (17) were isolated from the fruits of Terminalia chebula Retz. along with fourteen known ones. Their structures were elucidated by 1D and 2D NMR spectroscopic data and acid hydrolysis. After evaluating for Baker's yeast alpha-glucosidase, rat intestinal alpha-glucosidase, and porcine pancreatic alpha-amylase inhibitory activities of all the isolated compounds, 23-O-galloylarjunolic acid (11, IC50 21.7 mu M) and 23-O-galloylarjunolic acid 28-O-beta-D-glucopyranosyl ester (12, IC50 64.2 mu M) showed potent inhibitory activities against Baker's yeast alpha-glucosidase compared to the positive control, acarbose (IC50 174.0 mu M). However, all the tested compounds except for the positive control, acarbose, had no or only weak inhibitory activity against rat intestinal alpha-glucosidase and porcine pancreatic alpha-amylase. (C) 2016 Elsevier Ltd. All rights reserved.

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