Canine Pancreatic-Specific Lipase Concentrations in Dogs with Heart Failure and Chronic Mitral Valvular Insufficiency

초록

Background: Chronic mitral valvular insufficiency ( CMVI) in dogs is very common and might cause clinical signs of congestion and poor tissue perfusion. Hypothesis: Poor tissue perfusion from CMVI causes pancreatitis in dogs, as indicated by serum pancreatic lipase concentrations. Animals: Sixty- two client- owned dogs consisting of 40 dogs with different stages of heart failure from CMVI and 22 agematched healthy dogs, based on full cardiac exam and routine laboratory tests. Methods: Prospective, controlled, observational study. Serum canine pancreatic lipase immunoreactivity ( cPLI) concentrations were determined by quantitative cPLI test in healthy and CMVI groups. Results: Serum cPLI concentrations were 54.0 lg/ L ( IQR: 38.0- 78.8 lg/ L) in control, 55.0 lg/ L ( IQR: 38.3- 88.8 lg/ L) in ISACHC I, 115.0 lg/ L ( IQR: 45.0- 179.0 lg/ L) in ISACHC II and 223.0 lg/ L ( IQR: 119.5- 817.5 lg/ L) in ISACHC III. Close correlation to serum cPLI concentration was found in the left atrial to aorta ( LA/ Ao) ratio ( r = 0.597; P =.000) and the severity of heart failure ( r = 0.530; P =.000). Conclusions and Clinical Importance: This study found CMVI is associated with pancreatic injury in congestive heart failure caused by CMVI. Therefore, periodic monitoring on cPLI could be useful in monitoring dogs in heart failure.

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