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초록
Several phenylbutenoid dimer (PBD) analogs were synthesized and evaluated for their inhibitory activities against nitric oxide (NO) production and TNF- release. The PBD analogs were synthesized via Diels-Alder and subsequent Schlosser reactions as key steps. Among the tested compounds, two analogs (8c, 8f) exhibited much stronger inhibitory activity against LPS-stimulated NO production and TNF- release in RAW 264.7 cells than that of wogonin.
키워드
Phenylbutenoid dimers; Nitric oxide; TNF-alpha; Anti-inflammatory activity; Diels-Alder reaction; ZINGIBER-CASSUMUNAR; MACROPHAGES; RHIZOMES; WOGONIN
- 제목
- Synthesis and Anti-inflammatory Activity of Phenylbutenoid Dimer Analogs
- 저자
- Kim, Sung-Soo; Fang, Yuanying; Park, Haeil
- 발행일
- 2015-06
- 유형
- Article
- 권
- 36
- 호
- 6
- 페이지
- 1676 ~ 1680