Preparation and Release Property of Alginate Beads Immobilizing Poly(N-isopropylacrylamide-co-dimethylamino ethyl methacrylate)

초록

Alginate beads were prepared using poly (N-isopropylacrylamide-co-dimethylamino ethyl methacrylate) (P(NIPAM-co-DMAEMA)). First, P(NIPAM-co-DMAEMA) was immobilized on the surface of alginate beads by taking advantage of electrostatic interaction between alginate and P(NIPAM-co-DMAEMA). Second, P(NIPAM-co-DMAEMA) was contained in the matrix of alginate beads. P(NIPAM-co-DMAEMA) were prepared by a free radical polymerization at 74 degrees C for 12 h. The weight ratio of NIPAM to DMAEMA monomer was 95/5. The copolymer was identified by H-1-NMR. Releases from the alginate beads were observed at 30, 37, and 45 degrees C using blue dextran or FITC-dextran(fluorescein isothiocyanate-dextran) as a model drug. The effect of temperature on the degree of release from the beads was insignificant. FITC-dextran was released more than blue dextran possibly due to its smaller molecular weight.

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