DNA Damage Protection and Anti-inflammatory Activity of Different Solvent Fractions from Aruncus dioicus var. kamtschaticus

초록

This study investigated DNA damage protection and anti-inflammatory activity of different solvent fractions from Aruncus dioicus var. kamtschaticus (A. dioicus) aerial parts water extract. As for DNA damage protection, distilled water (H 2 O) fraction displayed the most powerful protection for DNA damage at a concentration of 1 ㎎/㎖. As for anti-inflammatory activity, dichloromethane (CH 2 Cl 2 ) fraction exhibited the highest NO inhibition activity, ranging from 61% to 19% (10-40 ㎍/㎖). Furthermore, the levels of pro-inflammatory cytokines mRNA expressions and intracellular reactive oxygen species (ROS) were employed to verify the anti-inflammatory activity of the CH 2 Cl 2 fraction on further researches. It could be concluded that A. dioicus had a significantly effect of DNA damage protection and anti-inflammatory activity which also as an essential edible vegetable and medicinal species.

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