Anti-angiogenic activity of the methanol extract and its fractions of Ulmus davidiana var. japonica

Jung, Hyun-Joo; Jeon, Hye-Jin; Lim, Eun-Ju; Ahn, Eun-Kyoung; Song, Yun Seon; Lee, Sanghyun; Shin, Kuk Hyun; Lim, Chang-Jin; Park, Eun-Hee

doi:10.1016/j.jep.2007.03.006

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Anti-angiogenic activity of the methanol extract and its fractions of Ulmus davidiana var. japonica

Jung, Hyun-Joo;
Jeon, Hye-Jin;
Lim, Eun-Ju;
Ahn, Eun-Kyoung;
Song, Yun Seon;
외 4명

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초록

This study aimed to elucidate anti-angiogenic activity of Ulmus davidiana var. japonica that has been widely used in folk medicine. The methanol extract (UDE) of Uhnus davidiana var. japonica concentration-dependently displayed a strong inhibition in the chick chorioallantoic membrane (CAM) angiogenesis. The n-butanol fraction of UDE and subsequent 30% MeOH subtraction were identified to be most responsible for the anti-angiogenic activity. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

키워드

Ulmus davidiana var. japonica; angiogenesis; anti-angiogenic; chorioallantoic membrane; Ulmaceae; MUSHROOM PHELLINUS-LINTEUS; TUMOR-GROWTH; PHARMACOLOGICAL-ACTIVITIES; ANTIANGIOGENIC ACTIVITY; GARDENIA-JASMINOIDES; NATURAL-PRODUCT; IN-VITRO; INHIBITION; MECHANISMS; COMPOUND

제목: Anti-angiogenic activity of the methanol extract and its fractions of Ulmus davidiana var. japonica

저자: Jung, Hyun-Joo; Jeon, Hye-Jin; Lim, Eun-Ju; Ahn, Eun-Kyoung; Song, Yun Seon; Lee, Sanghyun; Shin, Kuk Hyun; Lim, Chang-Jin; Park, Eun-Hee

DOI: 10.1016/j.jep.2007.03.006

발행일: 2007-06

유형: Article

저널명: Journal of Ethnopharmacology

권: 112

호: 2

페이지: 406 ~ 409