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A new neo-lignan from culture broth of Phellinus linteus and its dengue virus type-2 inhibition activity
- Kim, Young-Hee;
- Choi, Dae-Cheol;
- Ki, Dae-Won;
- Kim, Ji-Yul;
- Song, Jae-Hyoung;
- ... Ko, Hyun-Jeong;
- 외 2명
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1초록
Several species within the genus Phellinus are used as a traditional medicine for various health conditions. A new neo-lignan derivative, phelignan A (1), 1 ), and a known neo-lignan (2) 2 ) were isolated from the culture broth of P . linteus. . The chemical structures of the isolated compounds were determined using 1D- and 2D-NMR and MS data and by comparisons of the data with those reported in the literature. The anti-viral activity of the isolated compounds against dengue virus-2 (DENV-2) was evaluated. Compounds 1 and 2 exhibited anti-viral activity against DENV-2, with IC50 50 values of 1.45 and 2.15 mu M, respectively.
키워드
Phellinus linteus; Hymenochaetaceae; Neo-lignan; Dengue virus type-2 inhibition; INONOTUS-XERANTICUS; DAVALLIALACTONE
- 제목
- A new neo-lignan from culture broth of Phellinus linteus and its dengue virus type-2 inhibition activity
- 저자
- Kim, Young-Hee; Choi, Dae-Cheol; Ki, Dae-Won; Kim, Ji-Yul; Song, Jae-Hyoung; Ko, Hyun-Jeong; Lee, In-Kyoung; Yun, Bong-Sik
- 발행일
- 2024-10
- 유형
- Article
- 권
- 63
- 페이지
- 43 ~ 46
- 언어
- ENG
- 출판사
- ELSEVIER
- 발행국가
- 네덜란드
- 분량
- 4 페이지
- ISSN
- E 1876-7486
P 1874-3900