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초록
Background: miRNAs, a class of small endogenous RNAs, are one of the essential biopharmaceuticals which are in commercial spans as next-generation medicine in recent times. Aim of the Review: A snapshot of the current scenario regarding the miRNAs as biopharmaceuticals have been discussed. Key Scientific Concepts of Review: In this work, biopharmaceutical companies working with miRNAs and the current status of preclinical/clinical trials about miRNA therapeutics have been reviewed. Finally, recent updates on the absorption, distribution, metabolism, and excretion (ADME), as well as a delivery system of miRNAs, have been illustrated. (C) 2021 The Authors. Published by Elsevier B.V. on behalf of Cairo University.
키워드
miRNA; Next-generation medicine; Biopharmaceuticals; SYSTEMIC ENERGY HOMEOSTASIS; MICRORNA DELIVERY; DEGRADABLE DENDRIMERS; INSULIN-RESISTANCE; PANCREATIC-CANCER; DRUG-METABOLISM; EMERGING ROLE; HEPATITIS-C; SMALL RNAS; MIR-34A
- 제목
- Therapeutic advances of miRNAs: A preclinical and clinical update
- 저자
- Chakraborty, Chiranjib; Sharma, Ashish Ranjan; Sharma, Garima; Lee, Sang-Soo
- 발행일
- 2021-02
- 유형
- Article
- 권
- 28
- 페이지
- 127 ~ 138