Management of Meniere's Disease: How Does the Coexistence of Vestibular Migraine Affect Outcomes?

초록

Objective: To report the incidence of vestibular migraine (VM) in patients with Meniere's disease (MD) and investigate whether management outcomes of MD differ by the association of VM. Study Design: Retrospective cohort study. Setting: Tertiary care academic center. Patients: MD patients (n = 251) with/without VM who were managed for 5 years in a dizziness clinic. Main Outcome Measures: Influence of VM on management outcomes and hearing at the latest follow-up in stepwise management options. Results: Incidence of VM was 35% in MD patients. VM was more common in women than men (40 vs. 22%) and in probable MD than definite MD (43 vs. 29%). Bilateral MD was more frequent with coexistence of VM than without VM in definite MD (14 vs. 0%) as well as probable MD (24 vs. 7%). At the latest follow-up, preventive medications were effective in controlling vertigo in most (80%) patients (74%/ 90% in definite/probable MD). Additional intratympanic steroids were required in 16% (20%/10% in definite/probable MD) and intratympanic gentamicin or surgeries in 9 (6%) patients with intractable MD. The percentage of intractable MD did not differ with coexistence of VM, though definite MD showed a significantly higher percentage of intractable MD than probable MD (6 vs. 0%, respectively, p = 0.002). Worsening hearing was more frequent in definite MD than probable MD (19 vs. 4%), and association of VM did not influence the incidence of worsening hearing. Conclusions: Coexistence of VM was about 30 to 40% in definite and probable MD, especially frequent in bilateral MD (77%) and women with probable MD (50%), requiring identification of coexisting VM while managing MD patients. Management outcomes and worsening hearing in MD patients are not dependent on the coexistence of VM, when both are managed.

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