Synthesis of 2-Alkoxyaryl-2-aryl Enamines via Tandem Copper-Catalyzed Cycloaddition and Rhodium-Catalyzed Alkoxyarylation from Alkynes, N-Sulfonyl Azides, and Aryl Ethers

Shin, Seohyun; Park, Youngchul; Kim, Cheol-Eui; Son, Jeong-Yu; Lee, Phil Ho

doi:10.1021/acs.joc.5b00891

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Synthesis of 2-Alkoxyaryl-2-aryl Enamines via Tandem Copper-Catalyzed Cycloaddition and Rhodium-Catalyzed Alkoxyarylation from Alkynes, N-Sulfonyl Azides, and Aryl Ethers

Shin, Seohyun;
Park, Youngchul;
Kim, Cheol-Eui;
Son, Jeong-Yu;
Lee, Phil Ho

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45

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49

초록

A synthetic route to a wide range of 2-alkoxyaryl-2-aryl enamines is developed from Rh-catalyzed alkoxyarylation of N-sulfonyl-4-aryl-1,2,3-triazoles with aryl ethers via the elimination of nitrogen molecule. In addition, 2-alkoxyaryl-2-aryl enamines are prepared via tandem Cu-catalyzed cycloaddition and Rh-catalyzed alkoxyarylation starting from apes, N-sulfonyl azides, and aryl ethers in one-pot.

키워드

TERMINAL ALKYNES; CONTROLLING SELECTIVITY; AZAVINYL CARBENES; TRANSANNULATION; 1,2,3-TRIAZOLES; PYRROLES; 1-SULFONYL-1,2,3-TRIAZOLES; N-SULFONYL-1,2,3-TRIAZOLES; ANNULATION; TRIAZOLES

제목: Synthesis of 2-Alkoxyaryl-2-aryl Enamines via Tandem Copper-Catalyzed Cycloaddition and Rhodium-Catalyzed Alkoxyarylation from Alkynes, N-Sulfonyl Azides, and Aryl Ethers

저자: Shin, Seohyun; Park, Youngchul; Kim, Cheol-Eui; Son, Jeong-Yu; Lee, Phil Ho

DOI: 10.1021/acs.joc.5b00891

발행일: 2015-06-05

유형: Article

저널명: The Journal of Organic Chemistry

권: 80

호: 11

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