한국 · 중국 · 일본 당귀가 cyclophosphamide로 유발된 흰쥐의 빈혈에 미치는 영향의 차이

초록

The purpose of this study was to compare the hematopoietic effects of Angelica gigas, A. sinensis, and A. acutiloba extract (1g/kg B.W.) on cyclophosphamide-induced (30mg/kg B.W.) anemic rats. Cyclophosphamide injection group (AG, AS, AA) showed a decrease in weight gain in comparison with the normal group. Compared to the cyclophosphamide-treated control group, oral administration of Angelica gigas extract for 14 days in the normal group significantly prevented body weight loss. The iron level of the A. gigas-administered group was significantly higher than the control groups. The serum vitamin B12 level of A. gigas-, A. sinensis-, and A. acutiloba-administered groups was significantly higher than in the control. We suggest that administration of A. gigas, A. sinensis, and A. acutiloba prevents cyclophosphamide-induced anemia by improving hematological value and iron status.